The liver performs 500 different functions in the body—and can therefore easily become overwhelmed. So, multiple functionalities are attributed to this triangular organ extending across the abdominal cavity below the diaphragm.
Apparently, this organ is extremely vulnerable to numerous pathologies mainly associated with its great number of functions, structural organization, strategic localization and cell sensitivities.
During the past 30 years and even after the major progress in the liver disease management, millions of people still suffer from an acute or chronic liver condition worldwide. Liver diseases affect more than 10% of the world population and its mortal end-stage generally follows cirrhosis and liver cancer.
Oxidative stress has been considered a key causing factor of liver damage induced by a variety of agents, including alcohol, drugs, viral infections, environmental pollutants and dietary components, which in turn results in progression of liver injury, non-alcoholic steatohepatitis, non-alcoholic liver disease, liver fibrosis and cirrhosis. Nowadays, also through sugar consumption.
It is becoming very common, and increasingly common in younger people. The good news is that by fixing up the diet to avoid refined sugars and things that break down easily into sugar, you can take a big step towards avoiding fatty liver. Curcumin also helps, though! It’s been shown to lower liver enzymes which are the markers that are used to measure liver function.
Natural products provide a repertory for discovery of new leads that can be used in treating different types of diseases such as cancer, inflammation and liver diseases. More than half of all pharmaceutical products have been discovered from natural compounds or their derivatives.
Curcumin is the main constituent of turmeric, the rhizome of Curcuma longa. Curcuma is one of the most commonly used indigenous molecules endowed by various shielding functionalities that protects the liver. Derivatives from Curcuma longa L. are including, Curcumin, Ar-turmerone, Methylcurcumin, Demethoxy curcumin, Bisdemethoxy curcumin and Sodium curcuminate.
Studies results showed that curcumin exerts remarkable protective and therapeutic effects of oxidative associated liver diseases through various cellular and molecular mechanisms. Those mechanisms include suppressing the proinflammatory cytokines, lipid perodixation products, PI3K/Akt and hepatic stellate cells activation, as well as ameliorating cellular responses to oxidative stress such as the expression of Nrf2, SOD, CAT, GSH, GPx and GR. Taking together, curcumin itself acts as a free radical scavenger over the activity of different kinds of ROS via its phenolic, β-diketone and methoxy group. Further clinical studies are still needed in order to recognize the structure-activity relationships and molecular mechanisms of curcumin in oxidative associated liver diseases.
Curcumin is able to protect and treat liver diseases and to alter different cellular pathways. For instance, curcumin induce the expression of heme oxygenase-1 which cleaves heme and produces CO, biliverdien and bilirubin and other antioxidant molecules. Regarding the reported effects on cellular responses, curcumin inhibits activation and proliferation of HSC, leading to a decrease in production of extracellular matrix collagen and protecting liver from fibrogenesis.
A wide variety of preclinical studies support the effectiveness of dietary curcumin in the management of oxidative associated liver diseases. According to these articles, curcumin as a dietary supplement has a protective role against the onset of liver diseases. The intake of a significant content of curcumin in the daily regimen or as dietary supplementation along with restricted therapeutic options can provide perfect prevention and treatment for liver disorders.
If you wish to start preventing these type of conditions, please check our Turmeric capsules.
Be happy, stay healthy!